INFLAMMATORY SKIN DISEASES AND THEIR TREATMENT
The most common and important inflammatory skin diseases include neurodermatitis, psoriasis, acne and rosacea. We are also aware of many other dermatological diseases that we can of course treat in our practice. The exact diagnosis is important for the choice of therapy. That is why we use various diagnostic methods for clarification and, if necessary, carry out further special examinations such as biopsies or blood tests.
Psoriasis is one of the most common skin diseases. It is benign and often has a chronic course, and psoriasis often has different appearances and is genetically predisposed. The disease usually manifests itself in the persistent appearance of red dandruff patches, which occur, for example, in the hairy head, knee, elbow or perianal area. In very severe cases, the entire surface of the skin or joints, nails or mucous membranes can be affected. It is not known to infect other people.
If you recognize yourself based on this description and symptoms, you can reach us at any time and arrange a personal consultation. We can then clarify exactly whether it is psoriasis. If this is the case, we will advise you in detail about possible therapeutic measures. Together we will find the right therapy for you.
Neurodermatitis and eczema
Eczema is understood to be intolerance reactions of the skin, which can be of various origins. The exact causes of atopic dermatitis are unknown, but genetic predispositions are considered to be major risk factors.
Neurodermatitis is an endogenous eczema and is triggered by internal factors, often hereditary predispositions. This disease occurs in flares and is accompanied by persistent itching and dry, flaky and reddened skin. It often begins in childhood, but also occurs in adulthood.
Exogenous eczema is triggered by contact with substances that act on the skin. This contact can be felt and felt, or via the finest traces of substance in the air. In general, eczema can affect any part of the body. Not every stimulus triggers eczema, but the decisive factor is that the stimulus exceeds the skin’s tolerance threshold and this results in inflammation.
Inflammatory skin diseases in their various forms of eczema often look very similar, which is why an accurate evaluation is necessary. In our dermatological practice in Berlin-Mitte we check in detail what form you are dealing with. Based on an exact diagnosis, we can find appropriate therapy options for you or your child.
About 85 percent of the German population have suffered from acne at some point in their life. The main cause of acne is hormonal changes during puberty. The onset of acne differs from patient to patient, but it usually subsides by the age of 30. About 60 percent of young people suffer from so-called physiological acne, which decreases again after two to three years. This form of acne can usually be stopped with over-the-counter drugs from the drugstore or pharmacy. In contrast, around 40 percent of teenagers suffer from a pronounced form of the disease, known as clinical acne. This type of acne can sometimes last for five to twenty years and requires specialist medical treatment from a skin specialist doctor in delhi. The severe form of acne can lead to emotional stress, but this is not necessary. In our dermatological practice in Berlin we can find a therapy for every form of acne. If you suffer from acne, you can always contact us to arrange a personal consultation.
Rosacea is one of the most common skin diseases that occurs mainly in adulthood. Inflammatory skin diseases in the form of rosacea suffer around two to five percent of all adults in Germany, but women are much more likely than men. The disease usually begins between the ages of 30 and 50. In this disease, the fine veins of the skin are permanently dilated, which leads to reddening of the skin. Sudden facial redness, nodules, or pimples can be indicators of rosacea. As the disease progresses, the nose can become nodular and thickened. The predisposition to this disease is inheritable.
Treatment of other skin conditions such as acne inversa
Other skin diseases require surgical measures in addition to molecular therapies. This includes acne inversa – a severe form of acne. The skin becomes inflamed in parts of the body where skin folds easily form, for example in the armpits or in the genital area.
As the disease progresses, nodes and thickenings develop, including abscesses and fistulas. The latter are connecting passages to other organs or to the body surface. These can only be removed surgically .
“The inflammation has to subside before we cut out the affected tissue,” says Diana Crisan, dermatosurgeon at the University Hospital in Ulm. If antibiotics do not help, targeted molecular drugs, such as a TNF-alpha inhibitor, are used before the operation.
The use of active ingredients that specifically intervene in the inflammatory signaling pathways of acne inversa only became possible when experts had gained a deeper insight into the molecular processes involved in the development of the disease. As in many German clinics, there are research laboratories in Ulm where doctors and biologists work closely together.
Wound healing: New research
Scharffetter-Kochanek is looking for solutions to close non-healing wounds faster . The trigger for the healing disorder can be high blood pressure in the lower leg veins. This is caused by non-closing valves in the veins. The pressure forces red blood cells into the tissues of the skin.
Iron also gets into the wound area with them. Because iron forms dangerous radicals that can damage the genetic material, phagocytes eliminate the metal. The phagocytes can, however, become overactive due to the iron and trigger inflammatory reactions. This will prevent the wound from healing.
“We were looking for ways to intervene in this process,” explains Scharffetter-Kochanek. The researchers had the idea of using stem cells, precursor cells that can differentiate into different tissues. “These cellular all-rounders produce different substances, depending on whether they are in an acute or a chronic wound,” reports the dermatologist. In the iron-overloaded, non-healing areas of the skin, the stem cells release large amounts of a substance that blocks docking points for a messenger substance. This reprograms the phagocytes that have gotten out of control.
The first clinical studies in which mesenchymal stem cells were tested on a few patients with chronic wounds showed promising results – the open areas in the skin closed. Perhaps there will be a new way to treat chronic wounds in the near future.